Prognostic Factors for Persistent or Recurrent Disease of Papillary Thyroid Carcinoma with Neck Lymph Node Metastases and/or Tumor Extension beyond the Thyroid Capsule at Initial Diagnosis2005 90: 5723-5729 ปี 2548   Sophie Leboulleux, Carole Rubino, Eric Baudin, Bernard Caillou, Dana M. Hartl, Jean-Michel Bidart,Jean-Paul Travagli and Martin Schlumberger Departments of Nuclear Medicine and Endocrine Tumors (S.L., E.B., M.S.), Institut National de la Santé et de la Recherche Médicale U605 (C.R.), Pathology (B.C.), Surgical Oncology (J.-P.T., D.M.H.), and Clinical Biology (J.-M.B.), Institut Gustave Roussy, 94805 Villejuif Cédex, France   Context: Reliable prognostic factors are needed in papillary thyroid cancer patients to adapt initial therapy and follow-up schemes to the risks of persistent and recurrent disease.  Objective and Settings: To evaluate the respective prognostic impact of the extent of lymph node (LN) involvement and tumor extension beyond the thyroid capsule, we studied a group of 148 consecutive papillary thyroid cancer patients with LN metastases and/or extrathyroidal tumor extension. Initial treatment, performed at the Institut Gustave Roussy between 1987 […]

Cotreatment of Acromegaly with a Somatostatin Analog and a Growth Hormone Receptor Antagonist J Clin Endocrinol Metab 2005 90: 5627-5631 ปี 2548   Cotreatment of Acromegaly with a Somatostatin Analog and a Growth Hormone Receptor Antagonist Jens Otto Lunde Jørgensen, Ulla Feldt-Rasmussen, Jan Frystyk, Jian-Wen Chen, Lars Østergård Kristensen, Claus Hagen and Hans Ørskov Medical Department M (Endocrinology and Diabetes) (J.O.L.J., J.F., J.-W.C., H.Ø.), Aarhus University Hospital, DK-8000 C Aarhus, Denmark; Department of Endocrinology, Rigshospitalet (U.F.-R.), DK-2200 Copenhagen, Denmark; Department of Medicine and Endocrinology, Herlev Sygehus (L.Ø.K.), DK-2730 Copenhagen, Denmark; and Department of Endocrinology (C.H.), Odense University Hospital, DK-5000 Odense, Denmark Address all correspondence and requests for reprints to: J. O. L. Jørgensen, Medical Department M, Aarhus University Hospital, Norrebrogade 44, DK-8000 C Aarhus, Denmark. E-mail: jolj@dadlnet.dk . Context: Pegvisomant is a GH receptor antagonist that blocksthe peripheral actions of GH in acromegaly. Pegvisomant, incontrast to somatostatin (SMS) analogs, does not suppress theactivity […]

The Metabolic Syndrome, Insulin Resistance, and Cardiovascular Risk in Diabetic and Nondiabetic Patients 2005 90: 5698-5703 ปี 2548 Christoph H. Saely, Stefan Aczel, Thomas Marte, Peter Langer, Guenter Hoefle and Heinz Drexel Vorarlberg Institute for Vascular Investigation and Treatment (C.H.S., S.A., T.M., P.L., H.D.), Feldkirch 6800, Austria; and Department of Medicine, Academic Teaching Hospital Feldkirch (C.H.S., S.A., T.M., G.H., H.D.), Feldkirch 6800, Austria   Context: The contribution of insulin resistance per se to the vascular risk conferred by the metabolic syndrome (MetS) is not known; conversely, it is uncertain whether insulin resistance confers vascular risk beyond the entity of the MetS.  Objective: The objective of this study was to investigate the impact of the MetS (Adult Treatment Panel III criteria) and insulin resistance (as estimated by the homeostasis model assessment index) on the incidence of vascular events.  Design and Patients: This was a prospective cohort study enrolling 750 consecutive patients undergoing coronary angiography for the evaluation of coronary artery disease.  Setting: The study was performed at a tertiary care clinical research […]

Randomized, Single Blind Trial of Intravenous versus Oral Steroid Monotherapy in Graves? Orbitopathy Vol. 90, No. 9 5234-5240 ปี 2548   Randomized, Single Blind Trial of Intravenous versus Oral Steroid Monotherapy in Graves’ Orbitopathy George J. Kahaly, Susanne Pitz, Gerhard Hommel and Manuela Dittmar Departments of Medicine I (G.J.K., M.D.), Biology (M.D.), Ophthalmology (S.P.), and Medical Statistics (G.H.), Gutenberg University, Mainz 55101, Germany Address all correspondence and requests for reprints to: Dr. George J. Kahaly, University Hospital, Mainz 55101, Germany, E-mail: gkahaly@mail.uni-mainz.de . Context: Glucocorticoids are effective for severe Graves’ orbitopathy (GO), which causes substantial morbidity. The question at issue is how best to use them. Objective: The objective of this study was to optimize glucocorticoid application in GO. Design: The study design was a randomized trial over 12 wk with 6-month follow-up. Setting: The study was performed at university joint thyroid and ophthalmic clinics. Patients: Seventy euthyroid out-patients with untreated, active, and severe GO were studied. […]